Pyrrole, Kryptopyrrole, Pyrrole Disorder, Pyrrole Condition, Pyrroluria, Kryptopyrole, Pyroluria, Pyrrole Syndrome.
These are all names used to describe a chemical found in the urine which has been clinically shown to be associated with several chronic mental health issues. It has also historically been referred to as the MAUVE FACTOR.
No research has been conducted to show it is a condition, syndrome, or disorder, or genetic in origin.
Our research has shown:
A measure of pyrroles in urine is not a diagnosis, but a biomarker of oxidative stress.
For treatment, the stress must be managed for long term reduction of symptoms, along with re-balancing of biochemistry.
The correct term is: High or Elevated Urinary Pyrroles.
Urinary Pyrroles are unstable; thus it is essential that collection and transportation of urine is done under strict standardized conditions to maximize reliability of results. Poor collection and handling can result in false negative readings, or false positive.
No research has been conducted to show it is a condition, syndrome or disorder, autoimmune disease, or genetic.
To repeat. It is not a diagnosis, but a measure of oxidative stress which must be managed for long-term reduction of symptoms.
Work has also shown, as pyrroles in urine are a waste product, therefore unstable, it is essential that collection and transportation of urine is done under strictly standardized conditions to maximize the reliability of results. Poor collection and handling can result in false readings and poor patient outcomes.
What is important is the focus on the urine measure as a biomarker of oxidative stress which directs patient care to identify and manage the underlying oxidative stress. A doctor trained by Bio Balance Health will know how to do this and manage the process which is individualised to each patient.
The identification of High Urinary Pyrroles has changed many lives as reduction of the pyrrole measure commonly correlates with reduction of symptoms.
The understanding that very High Urinary Pyrroles is also often associated with some forms of mental ill-health has reduced the stigma and the loss of hope felt by many with a mental health diagnosis.
The process to reduce high pyrroles enhances current chronic health management.
Symptoms associated with high pyrrole vary as the underlying stress varies. This explains why there are so many symptoms and how each person with high urinary pyrroles manifests different responses. It is important your practitioner lists all your symptoms so which symptoms show treatment response can be observed. High Urinary Pyrroles are only found in certain types of mental health.
In 2018 Applied Analytical Laboratories became the first to have selectivity in their assay which enables the distinction between chemical species pyrrole from urobilinogen, and provides separate measures for both, as well as the CORRECT scientific measure of Specific Gravity (SG).
Urobilinogen is a by-product of normal gut function as opposed to oxidative stress and is co-measured in the assay.
Separation of these urine components allows for identification of additional pathologies (e.g. obstructed bile duct, haemolytic anaemia, or hepatitis) and is critical for correct interpretation.
The distinction allows a more accurate identification of the composition of the sample as treatment plans based on false results can exacerbate symptoms and/or lead to vitamin B6 toxicity.
The AAL Laboratory report will give clear reference ranges.
AAL recommends you use Bio Balance Health trained doctors who have experience in managing the process. Self-diagnosis and self-medication are fraught with difficulties and will not achieve optimal results.
Applied Analytical Laboratories Pty Ltd (AAL) is the only dedicated Pyrrole testing laboratory in Australia. AAL are the leaders in investigating the origin of elevated urinary pyrroles, both in their own processes and quality control, and through active research collaboration with university researchers.
SOME MORE SCIENCE
For those who want a bit more science.
The Pyrrole moieties that are measured are labile (reactive) intermediate fragments produced by the attack of reactive oxygen species on regulatory haem. This system has been suggested as a” last resort” anti-oxidant system of the body (bilirubin, for example, is a powerful anti-oxidant yet is physiologically toxic (we have scientific references for this).
The coordination, or reaction, between pyridoxine/pyridoxal and any pyrroles, or indoles, does NOT occur (if there was reaction of this nature all muscle contraction of every species on earth would not occur as serotonin/5HT is an indole).
No research has been performed or published to show Pyrrole is genetic or a disorder.
Conversely, we suggest that it is a condition manifested by excess oxidative stress.
Kryptopyrrole is 3-ethyl-2,4-dimethyl pyrrole and is used as one of the calibration references used for AAL’s assay.
Kryptopyrrole is NOT the active measured in the assay. It also has found successful application in our laboratory as a research chemical (where it has been used to produce HPL (the pyrroline-one form) and associated analogues for study. This work has made major inroads into elucidation of the mechanisms of the free radical oxidation (oxidation with reactive oxygen species).
Hydroxyhemepyrrolenone (aka HPL) is generated as an artifact during the testing process and is not the actual form of the analyte measured. HPL is also unstable (and rapidly disassociates) under the typically employed mildly acidic chromatographic conditions (which is why it is also difficult to measure accurately with current HPLC-MS technology).
Urobilinogen is a by-product of normal gut function, and levels can fluctuate greatly from morning to evening under normal circumstances, or times of adrenal stimulation/relaxation (through anxiety). It is not directly related to oxidative stress.
Separate measure of Urobilinogen can demonstrate other underlying issues which may present as mental distress, for example, biliary obstruction or renal failure. This makes this test very useful as an insight to other pathologies.