Pyrrole, Kryptopyrrole, Pyrrole Disorder, Pyrrole Condition, Pyrroluria, Kryptopyrole
Urine Collection Process for Pyrrole Analysis “Where do I go to get a Urine Pyrrole Test ?”
Get a Pyrrole Test Request Form
If your Doctor has provided you with an Applied Analytical Urinary Pyrrole Test request form, click to find your nearest collection agency.
If you are a new practitioner looking to refer a patient, please email to request a Urinary Pyrrole Test request form.
Patients must be naïve of zinc supplements or cease supplements 72 hours prior to tests if it’s the first time (to establish a base-line).
Do NOT cease Zinc if it is a follow-up test.
Medications used with Rheumatoid Arthritis and/and Urinary Tract Infections can interfere with the test, as does Rifampicin which changes the urine to a red/mauve colour. If you are taking these medications consult your physician as you will need to complete the course and/or abstain for a wash out period of 4 weeks prior to collecting a sample. For some, this is not possible.
Time Of Collection
Very high levels of urinary bilirubin DO also interfere. However this is rare and you will be informed if this is the case. The time of collection needs to be noted on the form in order to help account for obtained Urobilinogen levels.
Blood does NOT affect the test result, so spotting at the beginning or end of menstrual cycle will not interfere with the result. It is NOT recommended to collect during peak menstruation.
Use Applied Analytical Specimen Jar
Urine is to be collected in the supplied specimen jar and immediately covered with foil which protects it from light and heat and from incidental high energy electromagnetic radiation (EMR).
The sample is to be frozen immediately and kept covered and frozen from the time of collection until the time of testing in the laboratory.
Transport (Collection Agency)
Samples are transported in dry ice to keep the relative temperature below freezing (at -30oC). Your results will be sent back to your doctor.
Pyrrole Results very high or very low?
According to NPAAC guidelines, we will notify the practitioner when the urinary pyrrole result is greater than 400ug/dL, urobilinogen is greater than 16µmol/L, or other parameters are detected (such as, bilirubin, blood, ketones, protein, nitrites and leucocytes. These can illuminate if a patient has liver/kidney function issues, diabetes, infection or other protein dysregulation factors. Currently Applied Analytical Laboratories (AAL) is the only facility to meet this requirement and successfully participate in RCPA conducted proficiency programs for this system as an extra level of assurance.
As a result of our regulatory review and further research, what has changed is:
Improvement in the sensitivity of the testing process
Validated Reference Ranges
Reference ranges are now specific to adult Australians.
Distinct separation of pyrrole and urobilinogen, and the reporting of both.
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